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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DEPDC5
All Species:
13.03
Human Site:
T273
Identified Species:
31.85
UniProt:
O75140
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75140
NP_001007189.1
1572
177910
T273
E
W
T
S
L
L
V
T
I
K
K
L
F
I
Q
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_852875
773
87442
Cat
Felis silvestris
Mouse
Mus musculus
P61460
1527
173129
A248
V
L
V
R
L
E
Q
A
G
G
F
P
Q
G
D
Rat
Rattus norvegicus
NP_001100699
1456
164725
V221
D
R
T
G
Q
M
S
V
V
I
T
P
G
V
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517877
828
93963
Chicken
Gallus gallus
XP_415249
1571
177723
T273
E
W
T
S
L
L
V
T
I
K
K
L
F
I
Q
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_691450
1590
178752
T277
E
W
M
S
L
L
V
T
I
K
K
L
F
I
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728620
1472
168864
E237
K
S
L
D
E
F
P
E
H
M
R
D
C
L
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_794020
1608
181354
T284
E
W
H
G
L
L
Q
T
L
K
A
H
F
I
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7S9J6
2004
222187
T375
E
M
G
S
G
E
W
T
K
I
L
Y
Q
L
K
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
48
N.A.
91.7
87.4
N.A.
49.5
89.1
N.A.
75.5
N.A.
35.7
N.A.
N.A.
32.4
Protein Similarity:
100
N.A.
N.A.
48.6
N.A.
93.8
89.6
N.A.
50.9
94
N.A.
84.5
N.A.
53.7
N.A.
N.A.
48.6
P-Site Identity:
100
N.A.
N.A.
0
N.A.
6.6
6.6
N.A.
0
100
N.A.
93.3
N.A.
6.6
N.A.
N.A.
53.3
P-Site Similarity:
100
N.A.
N.A.
0
N.A.
6.6
33.3
N.A.
0
100
N.A.
93.3
N.A.
26.6
N.A.
N.A.
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
20
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
35.7
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
20
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
10
0
0
10
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% C
% Asp:
10
0
0
10
0
0
0
0
0
0
0
10
0
0
10
% D
% Glu:
50
0
0
0
10
20
0
10
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
10
0
0
0
0
10
0
40
0
0
% F
% Gly:
0
0
10
20
10
0
0
0
10
10
0
0
10
10
10
% G
% His:
0
0
10
0
0
0
0
0
10
0
0
10
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
30
20
0
0
0
40
0
% I
% Lys:
10
0
0
0
0
0
0
0
10
40
30
0
0
0
10
% K
% Leu:
0
10
10
0
50
40
0
0
10
0
10
30
0
20
0
% L
% Met:
0
10
10
0
0
10
0
0
0
10
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
10
0
0
0
0
20
0
0
0
% P
% Gln:
0
0
0
0
10
0
20
0
0
0
0
0
20
0
40
% Q
% Arg:
0
10
0
10
0
0
0
0
0
0
10
0
0
0
0
% R
% Ser:
0
10
0
40
0
0
10
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
30
0
0
0
0
50
0
0
10
0
0
0
0
% T
% Val:
10
0
10
0
0
0
30
10
10
0
0
0
0
10
10
% V
% Trp:
0
40
0
0
0
0
10
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _